Interleukin-6, interleukin-8 and interleukin-10 in estimating the severity of acute pancreatitis: an updated meta-analysis.

Hepatogastroenterology. 2014 Jan-Feb;61(129):215-20.

Zhang JNiu JYang J.


Early identification of severe AP can decrease the mortality rate and complications of SAP. The performance of IL-6 and IL-8 and IL-10 can act as markers of the severity of acute pancreatitis. Therefore, we aimed to evaluate the accuracy of IL-6, IL-8 and IL-10 in estimating the severity of acute pancreatitis.


MEDLINE and PubMed were searched from Jan 1990 to Nov 2012 for relevant studies. We calculated pooled sensitivities and specificities using the Dersimonian-Laird random-effect methods and generate the summary receiver operating curve and area under the curve was reported.


Twelve studies were eligible; 9 reports including 462 patients assessed the accuracy of IL-6 on day 1 of hospital admission, 5 reports including 208 patients on day 2, and 5 reports including 188 patients on day 3. Five studies (n = 299 patients) assessed the accuracy of IL-8 on day 1, and 4 (n = 182 patients) on day 2. They are 4 studies including 284 patients of IL-10 on day 1.


IL-6, IL-8, and IL-10 may be the predictive markers of SAP. But the best cut-off values and the controversial results of different research may be the largest problem. Therefore, multi-center research and large samples should be done to solve the present problem.

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